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alc Calculator

ALC Calculator

×10³/μL

White blood cells (WBC)

Lymphocytes

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An online ALC calculator helps to simply estimates absolute lymphocyte count corresponding to the white blood cell and lymphocytes count. So, account this absolute lymphocyte count calculator to estimates the CD4 count without sticking to complex and time consuming calculating procedures.

The calculator-online provided you with simple, but helpful stuff relevant to ALC or “absolute lymphocyte count”, let’s begin with evidence-based study-related ALC.

Evidence-Based Study (Absolute Lymphocyte Count or ALC):

In 1998, the study has been conducted by Shapiro et al. that simply account to determine whether the ALC or Absolute Lymphocyte count (stated as white blood count x lymphocyte %) can be taken into account to predict a low CD4 count.
There were 807 samples from inpatient, emergency, and clinical settings has been retrospectively analyzed by calculating:

  • Sensitivities;
  • Specificities;
  • Predictive values;
  • Likelihood ratios.

Out of which 322 results only (40%) had a CD4 count less than 200 cells/ mm3 and it has been found that ALC or Absolute Lymphocyte Count Values are lower than 1,000 cells/ mm3 predicted CD4 counts are less than 200 cells/ mm3 along with:

  • A sensitivity of 0.67;
  • A specificity of 0.96;
  • Positive predictive value of 0.91;
  • Negative predictive value of 0.81.

The given study depicted that there’s a reliable relationship exists between Absolute Lymphocyte Count and CD4 count and this can be taken into account to identify the patients who have high risk of opportunistic infection. Let’s begin with basic definition of “lymphocyte.”

What Are Lymphocytes?

Lymphocytes are white blood cells that work in a human immune system or it can be said as one of the body’s main types of immune cells. According to experts, the Lymphocytes are made in the bone marrow and often found in the blood and lymph tissue. They assist to fight off diseases, so it’s normal to see a temporary increase after an infectious disease. These are the six main types of WBC’s an average percentage of each type in the blood:

  • Lymphocytes – 30 percent
  • Neutrophils – 58 percent
  • Eosinophils – 2 percent
  • Basophils – 1 percent
  • Bands – 3 percent
  • Monocytes – 4 percent

The absolute lymphocytes are only the thing that matters for tracking CLL progression.

Well, track lymphocytes absolute count with not the lymphocytes percentage; forget WBC or white blood cell count.

Remember that, when the lymphocytes absolute count doubles within 6 months are said to be as lymphocyte doubling time.

Absolute Lymphocyte Count Formula:

The ALC formula is as follow:

ALC = WBC count x 1000 x %Lymphs

Where;

(WBC) represents the values of the white blood cell count

(LYMPH %) represents the lymphocyte percentage

Take this absolute lymphocyte count calculation formula into account to know about the absolute, high, low, normal lymphocyte count.

The above alc calculator also uses the same formula while calculating the lymphocytes absolute count.

Types of Lymphocytes:

Lymphocytes are mainly divided into T cells, B cells, and NK cells. Read on to know about these terms

T Cells:

T cells or T lymphocytes get their names as these cells are developed in the thymus gland. The T lymphocytes are assisting the body to kill cancer cells and even control the immune response to foreign substances. These cells are programmed to recognize, respond to and remember antigens. Studies show that T cells contribute to the immune defenses in two major ways – some direct and regulate immune responses and the others are able to destroy targeted cells on direct contact.

B Cells:

B cells or B lymphocytes are set to make one specific antibody. These cells are an important part of an immune system. B cells get their name as these lymphocytes mature in the bone marrow of humans, and even in the bursa organ of birds. Well, B cells are distinguished from other lymphocytes by a protein on their surface said to be as the B-cell receptor. Keep in mind, this protein is specialized to recognize and even attach to specific antigens. In simple words, these cells do their job to make antibodies that are protein produced by an immune system to combat foreign substances called antigens.

NK Cells:

NK or natural killer cells are lymphocytes that are said to be cytotoxic. NK cells also come from the same place as B and T cells. NK cells function similarly to cytotoxic T cells – people often confused that NK and T cells are the same, but they not! NK cells do not have T cell receptors or trigger antibody production, but NK cells are capable of distinguishing infected cancerous cells from normal cells.

The Terms About CD4 Count (Explore Know):

Typically, determining CD4 count from ALC or Absolute Lymphocyte Count is used of actual testing just because the elaborate method required that really takes a long time.

CD4 T lymphocytes are referred to as the laboratory immune indicator in patients with an immunodeficiency virus and even monitor the efficiency of anti-retroviral therapy and the progression of the virus towards the immunodeficiency syndrome (AIDS).

The given parameters in the table introduce the correlation between ALC and CD4 levels.

table

Absolute Lymphocyte Count (ALC) Calculator:

An online ALC calculator helps to estimates the absolute lymphocyte count from the WBC or white blood cell count and lymphocytes % and correlates it with CD4 levels in HIV monitoring. The estimations that you get from this tool is very useful in the assessment of the risk connected with viral infections and several other conditions like chronic lymphocytic leukemia and lymphomas.

When to Used This absolute lymphocyte count calculator:

  • The lymphocytes count calculator frequently used in the ED or Emergency Department setting as CD4 tests take longer to come back and even need patient consent
  • The calculator in limited-resource settings where CD4 count tests are expensive or unavailable

Why Use This Cd4 Count Calculator:

  • This tool serves great for CD4 count in HIV patients who seeking for antiretroviral therapy (control HIV infection) in resource -limited areas

How to Calculate Absolute Lymphocyte Count (ALC) With This Absolute Lymphocyte Calculator:

The ALC calculator is 100% free health tool and packed with user-friendly interface that helps you in calculating absolute lymphocytes count. Well, ahead to know the step-by-step guide of this absolute lymphocyte count calculator.

Inputs:

  • First of all, you just have to enter the WBC or White Blood Cells count in the designated field of this tool
  • Next, simply add the LYMPH % or Lymphocytes percentage into the given box
  • Once done, make a click on calculate button

Outputs:

The calculator will show:

  • Absolute Lymphocyte Count (ALC)
  • Correlation between ALC and predicted CD4 count

For a healthy person, the total lymphocyte count range should be between 1.5 and 3 ×10³ cells/μL.

Remember That The white blood cells (WBC) should be reported in cells per cubic millimeter – for instance, enters 7.3 for 7300 WBC per cubic millimeter of blood!

Normal Ranges And Levels:

Optimistic studies reveal that lymphocyte levels can vary according to an individual’s race, gender, location, and even lifestyle habits.

According to experts, the normal lymphocyte count range in adults is between 1,000 and 4,800 lymphocytes in 1 microliter (µL) of blood. When it comes to children, the absolute lymphocyte count normal range is between 3,000 and 9,500 lymphocytes in 1 µL of blood.

Typically, high or low lymphocyte count can be a sign of disease.

So, what does it mean if levels are high or low! Read on to know more about them!

If Levels Are High:

Well, come the point, several studies show that abs lymphocytes range above the normal range can be harmless and said to be a temporary situation just because of the body’s normal response to an infection or inflammatory infection.

But, low lymphocyte count can also refer to a sign of lymphocytosis, which is a more serious condition.

Lymphocytosis is the condition that frequently associated with some blood cancers, chronic infections, and autoimmune diseases like inflammatory bowel disease.

In an adult, the lymphocytosis is corresponding to a lymphocyte count higher than 3,000 lymphocytes in 1 µL of blood, experts say. When it comes to children, it would be around 9,000 lymphocytes in 1 µL of blood, although this value can be varied with age.

If Levels Are Low:

A low lymphocyte count below the normal range can say to be as temporary. The low absolute lymphocytes can occur when an individual prone to cold or another infection, or even be caused by intense physical exercise, malnutrition, or severe stress.

The absolute lymphocytes low can also refer as a condition known as lymphocytopenia or lymphopenia, usually occurs because

  • An individual body isn’t producing enough lymphocytes
  • Lymphocytes are being destroyed
  • Lymphocytes are trapped in an individual spleen or lymph nodes

Remember that Lymphocytopenia can also be occurring due to a side effect of medications or some other medical treatments.

A low lymphocytes count is a sign of lymphocytopenia change for adults and children. Several studies reveal that they are often less than 1,000 lymphocytes in 1 µL of blood for adults and less than 3,000 lymphocytes in 1 µL of blood for children.

What Causes A High Lymphocyte Count?

Lymphocytosis or a high lymphocyte count is very common if an individual had an infection. High lymphocyte levels may leads to a more serious illness or disease such as:

  • Viral Infections – such as (Measles, Mumps, and Mononucleosis)
  • Adenovirus
  • Hepatitis
  • Influenza
  • Tuberculosis
  • Toxoplasmosis
  • Cytomegalovirus
  • Brucellosis
  • Vasculitis
  • Acute Lymphocytic Leukemia
  • Chronic Lymphocytic Leukemia
  • HIV and AIDS

 

When to Worry About Low Lymphocytes?

Keep in mind, a low lymphocyte count cannot cause any signs or symptoms. Usually, the low lymphocytes symptoms are found when an individual is get tested for other diseases or conditions, such as AIDS.

Additionally, get a lymphocytes blood test and consult your doctor according to the results!

An individual may be at risk of lymphocytopenia

  • If an individual had a recent infection or surgery
  • If an individual have an underlying condition that can cause lymphocytopenia
  • If an individual intake any medications, which may affect higher lymphocyte count

So, if you have one of these, then there is a need to consult with medical experts ASAP!

Optimists studies reveal that if an individual has unusual infections, repeat infections, or such infections that won’t go away, then the health care provider may suspect that he/she have lymphocytopenia. Fever is the most common symptom of such an infection.

However, there are several other conditions that can cause lymphocytopenia such as

  • HIV and AIDS
  • Autoimmune Conditions – like Lupus
  • Undernutrition
  • Influenza
  • Some Cancers – such as (lymphocytic anemia, lymphoma, and Hodgkin disease)
  • Steroid Use
  • Radiation Therapy
  • Certain Drugs – like (Chemotherapy Drugs)
  • Some Inherited Disorders – including (Wiskott-Aldrich Syndrome and DiGeorge Syndrome)

FAQ’s (Absolute Lymphocyte Count or ALC):

What is ALC count?

The ALC is the count that assesses the number of lymphocytes from a certain volume of blood and predicts CD4 count.

What is ALC in blood test?

A ALC or absolute lymphocyte count of patient is representation of the number of lymphocytes in a certain volume of blood and generally is of a CBC/DIFF or Complete Blood Count with Differential.

How do I calculate cd4 count?

In immune-reconstituted, virologically suppressed (reducing the function and replication of a virus) and clinically stable HIV-infected adults, the CD4 easily and accurately estimated by simply multiplying the absolute count by a baseline CD4%.

What is the normal cd4 percentage for a healthy person?

In adults and teens, a normal CD4 count ranges from 500-1,200 cells/mm3. Generally, a normal CD4 count said to be as the means that your immune system is not yet significantly affected by HIV infection. A low CD4 count referred to as your immune system has been affected by HIV and/or the disease is progressing. The average normal CD4 count % for an individual who is HIV negative is about 40%. Remember that the normal range is anywhere from about 25% to 65%.

How can I lower my lymphocytes count?

To lower your high white blood cell count, all you need to include the following in your diet plan:

  • Vitamin C
  • Antioxidants
  • Omega-3 fatty acids
  • Don’t intake foods that consists of adequate amount of sugar, fat, and salt

What are the symptoms of low lymphocytes?

Individuals who have low numbers of lymphocytes are at increased risk of infection from bacteria, viruses, fungi, and parasites.

Symptoms of low lymphocytes are:

  • Fever
  • Cough
  • Runny nose
  • Skin rash
  • Infection that do not get better
  • Swelling in the spleen/lymph nodes
  • Swelling in the joints

Can stress cause low lymphocytes?

Dr. Calabrese reveals that stress decreases the body’s lymphocytes (the white blood cells that assist to fight off infection). Experts depicted that the lower your lymphocyte level, the more at risk you’re for viruses.

What is the treatment for high lymphocytes?

All you need to stick to a healthy diet plan, get plenty of rest, and even avoid germs since your body recovers its lymphocyte levels. You should have to consume a nutrient-rich diet to feel better and more energized. Also, your health care providers can assists you to choose whole foods that are right for you and packed with protein, minerals, carbs, fats, and vitamins.

Do lymphocytes fight viruses?

Lymphocytes helps to fight infections by producing antibodies, these are the chemicals that helps your body stop and even then remove foreign invaders such as viruses, bacteria, fungi, parasites, and toxic chemicals.

How do B lymphocytes fight infection?

B-cells are a role to fight bacteria and viruses by making Y-shaped proteins known as antibodies, these are specific to each pathogen and are able to lock onto the surface of an invading cell and even mark it for destruction by other immune cells.

Disclaimer:

Thankfully, the above absolute lymphocyte count calculator helps to calculate ALC. But, this tool takes into account for educational purposes only. Remember that, the outcomes should not be utilized for the diagnosis or treatment of any health problem or disease. Also, the result is not intended to replace clinical judgment, for the further query you have ahead to your Health Care Provider!

References:

From the source of pubmed ncbi: Correlation among total lymphocyte count, absolute CD4+ count, and CD4+ percentage in a group of HIV-1-infected South African patients

From the source of Wikipedia: Lymphocytosis (along with causes and diagnosis):

From the source of medicalnewstoday: Types of lymphocytes and Normal ranges and levels

From the source of healthline: Lymphocytes and how they work (explore all)