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Allele Frequency Calculator

Allele Frequency Calculator

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Calculate:

Common Homozygotes:

Heterozygotes:

Rare Homozygotes:

Given in:

Occurrence of the disease:

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This allele frequency calculator online lets you determine the relative frequency of carrying a gene that may cause a specific genetic disease in your offspring. You can also use our Hardy Weinberg calculator online to indicate the genetic diversity of a population with respect to population genetics.

What is Allele Frequency?

In biological terms:

“The number of individual alleles of a certain type of gene that represents a variant in a population is termed as allele frequency”.

In simple words, we can say that allele frequency explains how familiar an allele is within a population. And, it is also known as gene frequency. Alleles are the development of a gene that is found at the same position, or genetic locus on a chromosome. You can also determine the value of alleles by using the allele calculator. The frequency is generally defined in terms of the percentage related to the gene/allele and you can calculate allele frequency percentage by using our allele frequency calculator tool within no minutes.

Genotype Frequency:

“The percentage of individuals in a population that contains a specific genotype is termed as genotype frequency”.

Genotype frequencies represent the distribution of specific genetic variation in a population. Now you must think about how to calculate genotype frequency, you do not need to think about more since we provide you with an online genotype frequency calculator to perform calculations quickly.

Phenotype Frequency:

“The specific number of individuals in a population that have a particular observable trait or phenotype is known as phenotype frequency”.

Whether you want to know how to calculate phenotype frequency instantly, you can use our phenotype frequency calculator which performs calculations in a couple of seconds.

Gene Frequency:

“The ratio of a specified allele in a population to the total number of alleles at its genetic locus is termed as gene frequency”

Users can use this online gene frequency calculator to estimate the ratio of the total number of alleles regarding gene diversity.

How to Calculate Allele Frequency?

Allele frequency determines by using the Hardy Weinberg equation and this equation relates to genotype and phenotype frequencies for the population. It is also known as the allele frequency equation. In simple words, we can say that the Hardy-Weinberg equilibrium and allele frequency formula relate to each other.

The equation is given as:

p² + 2pq + q² = 1

Where:

  • p² represents the frequency of people that contain two healthy alleles. Also, it is known as homozygous dominant (AA)
  • 2pq represents the frequency of people who own one healthy and one impaired gene: the carriers. It is also expressed as heterozygous (Aa)
  • q² represents the frequency of people that have two impaired genes: the people with the disease and also termed as homozygous recessive (aa).
  • 1 represents a whole population that owns a certain gene

Solved Example:

A person has a specific disease, and his wife is also a carrier of a certain disease. He wants to know what’s the probability that he’s a carrier too if homozygotes have 55, heterozygotes contain 54, and rare homozygotes are 5. How to find allele frequency?

Solution:

Healthy Allele Frequency (p) = 0.7193 (%)
Mutant Allele Frequency (q) = 0.2807 (%)
Two healthy alleles p² = 0.5174
One healthy, and one mutant allele 2pq = 0.4038
Two mutant alleles q² = 0.0788

Whether you want to calculate the allele frequency by using the hardy weinberg equation, you can simply use our Hardy Weinberg equation calculator.

How Does the Allele Frequency Calculator Work?

Our online Hardy Weinberg calculator allows you to perform carrier frequency calculations regarding alleles within a few clicks. Let’s find how!
Input:

  • At first, select the option whether you want to be simple or advanced calculations
  • Once you make the selection, enter the values of parameters into the designated box
  • Simply click on the “Calculate” button

Output:
This Hardy Weinberg calculator determines the following results:

  • Healthy or Mutant allele frequency in percentage
  • People with one or two healthy alleles
  • People with one or two mutant alleles

FAQ’s:

How do you calculate allele frequency?

An allele frequency can be determined by dividing the number of times the allele interested observed in a population by the total number of copies of all the alleles at that specific genetic locus in the population. The best option to calculate the allele frequency is using an online allele frequency calculator.

How to calculate allele frequency and genotype frequency?

Since there are two possibilities and they have to add up to 100%, p + q = 1. Once you know the allele frequency, it also indicates the genotype frequency. The expected genotype frequencies of the two given alleles are calculated as shown in the given table.

Genotype Expected Frequency
aa or A2A2 q * q = q^2

Besides, you can also determine the genotype frequency with the assistance of a genotype frequency calculator to perform calculations easily.

How is phenotype frequency calculated?

The relative phenotype frequency for each phenotype can be estimated by counting the number of times a certain phenotype represent in a population and dividing it by the total number of individuals in the population.

What is Homozygous and Heterozygous?

In the human body, the cell has two copies of the same gene and two alleles of the same are varied and referred to as homozygous. On the other hand, in the cell, there are two copies of a gene is known as heterozygous.

Is allele and gene the same?

No, an allele is a variant form of a gene. Each gene lives at a distinct locus (location on a chromosome) in two copies and one of the copy genes is inherited from each parent. However, both copies are not necessarily the same.

How many alleles are in a gene?

A gene may have multiple different alleles, but there are two alleles present at the gene’s locus in any individual.

Who has stronger genes mother or father?

Generally, genes from your father are more dominant than compared to those inherited from your mother.

Are alleles dominant or recessive?

The most common interaction between alleles in a dominant/recessive relationship is that an allele of a given gene is said to be dominant when it actually overrules the other (recessive) allele.

Is it an allele A trait?

No, both are different. The main difference between allele and trait is that an allele is an alternative form of a specific gene while a trait is a character that is specified by the allele

Conclusion:

In a population, allele frequencies play an important role in genetic diversity. When allele frequency changes over time, it indicates that genetic drift is occurring and new mutations have been introduced into the population. Also, you can calculate the frequency allele of a gene with help of this online allele frequency calculator with a few steps.

Reference:

From the source of Wikipedia: Allele frequency,  Calculation of allele frequencies from genotype frequencies
From the source of Khan academy: Allele frequency & the gene pool, Darwin meets Mendel—not literally, Microevolution and population genetics, Example: Finding allele frequency
From the source of Study.com: Allelic Frequency: Definition & Explanation, What Is Allelic Frequency?, Allelic Frequency and Diploids